Water-Soluble Fullerene (C60) Derivatives as Nonviral Gene-Delivery Vectors
نویسندگان
چکیده
منابع مشابه
Water-Soluble Fullerene (C60) Derivatives as Nonviral Gene-Delivery Vectors
A new class of water-soluble C60 transfecting agents has been prepared using Hirsch-Bingel chemistry and assessed for their ability to act as gene-delivery vectors in vitro. In an effort to elucidate the relationship between the hydrophobicity of the fullerene core, the hydrophilicity of the water-solubilizing groups, and the overall charge state of the C60 vectors in gene delivery and expressi...
متن کاملMembranotropic properties of the water soluble amino acid and peptide derivatives of fullerene C60.
The modifying effects of the products of the equimolar addition Of DL-alanine and DL-alanyl-DL-alanine to fullerene C60 on the structure and permeability of the lipid bilayer of phosphatidylcholine liposomes has been studied using the luminescence probe technique. It is shown that these water soluble amino acid and dipeptide derivatives of fullerene (C60-AD) are quenchers of pyrene fluorescence...
متن کاملFullerene C60 and its derivatives as nanocomposites in polymer nanofibres
This work describes the application of oxo-derivatives of fullerene C60 and pristine fullerene as a nanocomposite in polymerous nanofibres. In this work we used oxofullerene derivative, of which preparation was presented by the authors of the State office for nuclear safety (Prague) on Nanocon 2009 and on Nanocon 2010 [1, 2]; there was presented its application in vivo as a radioprotective agen...
متن کاملAnti-Influenza Activity of C60 Fullerene Derivatives
The H1N1 influenza A virus, which originated in swine, caused a global pandemic in 2009, and the highly pathogenic H5N1 avian influenza virus has also caused epidemics in Southeast Asia in recent years. Thus, the threat from influenza A remains a serious global health issue, and novel drugs that target these viruses are highly desirable. Influenza A RNA polymerase consists of the PA, PB1, and P...
متن کاملAlkyl sulfonyl derivatized PAMAM-G2 dendrimers as nonviral gene delivery vectors with improved transfection efficiencies.
Amphiphilic dendrimer-based gene delivery vectors bearing peripheral alkyl sulfonyl hydrophobic tails were constructed using low-generation PAMAM-G2 as the core and functionalized by means of the aza-Michael type addition of its primary amino groups to vinylsulfone derivatives as an efficient tool for surface engineering. While the unmodified PAMAM-G2 was unable to efficiently transfect eukaryo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2008
ISSN: 1543-8384,1543-8392
DOI: 10.1021/mp700106w